Thisworkdiscusses howtoachieveworst-case Out-Of-Distribution(OOD) generalization for avariety of distributions based on arelatively small labeling cost.

Deep learning models have been widely used to assist doctors with clinical decision-making.

Deep learning-based approaches have achieved great success in the semantic segmentation [24, 43, 2, 7, 42, 3, 17, 10], thanks to a large amount of fully annotated data. However, collecting large-scale accurate pixel-level annotations can be extremely time and cost consuming [6]. An appealing alternative is to use off-the-shelf simulators to render synthetic data for which groundtruth annotations are generated automatically [33, 34, 32]. Unfortunately, models trained purely on simulated data often fail to generalize to the real world due to thedomain shifts.

Semantic segmentation is a popular task in computer vision, which assigns pixel-wise semantic labels for given images. It has been widely utilized to facilitate downstream applications such as video surveillance and autonomous driving. Recent progress on image semantic segmentation has been drivenbydeep neural networks trained onalargeamount oflabeled data, which are yet expensive to obtain. An alternative way is to generate synthetic images with pixel-level ground truth readily available in an effortless way [1,2].

Unsupervised domain adaptation (UDA) for semantic segmentation has been attracting attention recently, as it could be beneficial for various label-scarce real-world scenarios (e.g., robot control, autonomous driving, medical imaging, etc.). Despite the significant progress in this field, current works mainly focus on a single-source single-target setting, which cannot handle more practical settings of multiple targets or even unseen targets. In this paper, we investigate open compound domain adaptation (OCDA), which deals with mixed and novel situations at the same time, for semantic segmentation. We present a novel framework based on three main design principles: discover, hallucinate, and adapt. The scheme first clusters compound target data based on style, discovering multiple latent domains (discover).

Pre-trained diffusion models have shown great potential in real-world image super-resolution (Real-ISR) tasks by enabling high-resolution reconstructions. While one-step diffusion (OSD) methods significantly improve efficiency compared to traditional multi-step approaches, they still have limitations in balancing fidelity and realism across diverse scenarios. Since the OSDs for SR are usually trained or distilled by a single timestep, they lack flexible control mechanisms to adaptively prioritize these competing objectives, which are inherently manageable in multi-step methods through adjusting sampling steps. To address this challenge, we propose a Realism Controlled One-step Diffusion (RCOD) framework for Real-ISR. RCOD provides a latent domain grouping strategy that enables explicit control over fidelity-realism trade-offs during the noise prediction phase with minimal training paradigm modifications and original training data. A degradation-aware sampling strategy is also introduced to align distillation regularization with the grouping strategy and enhance the controlling of trade-offs. Moreover, a visual prompt injection module is used to replace conventional text prompts with degradation-aware visual tokens, enhancing both restoration accuracy and semantic consistency. Our method achieves superior fidelity and perceptual quality while maintaining computational efficiency. Extensive experiments demonstrate that RCOD outperforms state-of-the-art OSD methods in both quantitative metrics and visual qualities, with flexible realism control capabilities in the inference stage.

Healthcare providers often divide patient populations into cohorts based on shared clinical factors, such as medical history, to deliver personalized healthcare services. This idea has also been adopted in clinical prediction models, where it presents a vital challenge: capturing both global and cohort-specific patterns while enabling model generalization to unseen domains. Addressing this challenge falls under the scope of domain generalization (DG). However, conventional DG approaches often struggle in clinical settings due to the absence of explicit domain labels and the inherent gap in medical knowledge. To address this, we propose UdonCare, a hierarchy-guided method that iteratively divides patients into latent domains and decomposes domain-invariant (label) information from patient data. Our method identifies patient domains by pruning medical ontologies (e.g. ICD-9-CM hierarchy). On two public datasets, MIMIC-III and MIMIC-IV, UdonCare shows superiority over eight baselines across four clinical prediction tasks with substantial domain gaps, highlighting the untapped potential of medical knowledge in guiding clinical domain generalization problems.